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Types of high blood pressure medication

High blood pressure (hypertension) can be treated with different types of medicine. Sometimes, people with high blood pressure need to take more than 1 medicine to lower their numbers. Some of these medications are also available as a combination, so you can get 2 medicines in 1 pill or tablet.

Angiotensin-converting enzyme (ACE) inhibitors

ACE inhibitors stop the body from making angiotensin II. Angiotensin II is a hormone that causes blood vessels to narrow. ACE inhibitors help the blood vessels to relax and allow blood to flow more freely. This can help lower blood pressure.

Angiotensin II receptor blockers (ARBs)

ARBs block the action of angiotensin II, though your body will still make the hormone. ARBs cause the blood vessels to relax and reduce your blood pressure.

Beta blockers

Beta blockers work to limit the nerve impulses to the heart and blood vessels. This lowers your blood pressure by making the heart slow down and pump with less force.

Calcium channel blockers (CCBs)

CCBs block calcium from entering the muscle cells of the heart and blood vessels. This relaxes the blood vessels and lowers your blood pressure.

Diuretics

Diuretics, or "water pills," lower blood pressure by working in the kidneys to flush excess water and salt (sodium) from the body.

You and your doctor can discuss which medicine, or combination of medicines, may work best for you. All medicines are just a part of your blood pressure management plan. A complete plan also covers lifestyle, diet, and exercise. Each part of your plan works with the other to help you get to goal.

Important Safety Information

WARNING: EDARBI and EDARBYCLOR can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.

  • Before taking EDARBI or EDARBYCLOR, tell your doctor if you are breastfeeding or plan to breastfeed. Discuss with your doctor other ways to lower your blood pressure. It is not known if EDARBYCLOR passes into breast milk. You and your doctor should decide if you will take EDARBI or EDARBYCLOR or breastfeed. You should not do both.
  • Do not take EDARBYCLOR if you make less urine because of kidney problems (anuria).
  • Do not take aliskiren-containing products with EDARBI or EDARBYCLOR if you have diabetes.
  • Tell your doctor about all your medical conditions, including if you have heart problems or stroke, have gout, or have liver or kidney problems. Kidney problems may become worse in people that already have kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose or may need to stop treatment with EDARBYCLOR.
  • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other medicines to treat your high blood pressure or heart problem; water pills (diuretics); lithium; or digoxin.
  • EDARBI and EDARBYCLOR may cause serious side-effects including low blood pressure (hypotension) which may cause you to feel faint and dizzy. Vomiting and diarrhea, a low salt diet, sweating a lot, or not drinking enough fluid can also lead to low blood pressure.
  • If you feel faint or dizzy, lie down and call your doctor right away. If you pass out (faint) have someone call your doctor or get medical help. Stop taking EDARBYCLOR.
  • If you have fluid and body salt (electrolytes) problems, tell your doctor if you experience any of the following symptoms: dry mouth, confusion, thirst, lack of energy/weakness, drowsiness, passing very little urine or passing large amounts of urine, seizures, muscle pain/cramps, restlessness, muscle tiredness (fatigue), fast or abnormal heartbeat, nausea and vomiting, or constipation.
  • People who have increased levels of uric acid in the blood may develop gout. If you already have gout tell your doctor about worsening of your gout symptoms.
  • In clinical studies, the most common side effect seen with EDARBI was diarrhea (2.0%).
  • In clinical studies, the side effects seen with EDARBYCLOR included dizziness (8.9%) and tiredness (2.0%).

Please talk to your healthcare professional and see complete Prescribing Information for EDARBI and EDARBYCLOR.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Indications

EDARBI and EDARBYCLOR are prescription medicines used to treat high blood pressure (hypertension). Your doctor may prescribe other medicines for you to take along with EDARBI or EDARBYCLOR to treat your high blood pressure. EDARBYCLOR is used when one medicine is not enough or as the first medicine if your doctor decides you are likely to need more than one medicine. Medicines that lower your blood pressure may lower your chances of having a stroke or heart attack, but they don't work alone. They should be part of a complete treatment plan.